Do leukocyte telomere length dynamics depend on baseline telomere length? An analysis that corrects for ‘regression to the mean’
نویسندگان
چکیده
منابع مشابه
Leukocyte telomere length: the telomere tale continues.
In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...
متن کاملIs Leukocyte Telomere Length Related with Lung Cancer Risk?: A Meta-Analysis
Background: Epidemiological studies have probed the correlation between telomere length and the risk of lung cancer, but their findings are inconsistent in this regard. The present meta-analysis study has been carried out to demonstrate the association between relative telomere length in peripheral blood leukocytes and the risk of lung cancer using an established Q-PCR technique. Methods:...
متن کاملHomocysteine levels and leukocyte telomere length.
OBJECTIVE Elevated plasma homocysteine is a risk factor for vascular diseases, possibly due to homocysteine-mediated increase in oxidative stress and inflammation. As leukocyte telomere length (LTL) registers the cumulative oxidative stress and inflammation, we examined the relationship between homocysteine and LTL. METHODS LTL was measured using the Southern blot method. The relationship bet...
متن کاملAberrant leukocyte telomere length in Birdshot Uveitis
PURPOSE Birdshot Uveitis (BU) is an archetypical chronic inflammatory eye disease, with poor visual prognosis, that provides an excellent model for studying chronic inflammation. BU typically affects patients in the fifth decade of life. This suggests that it may represent an age-related chronic inflammatory disease, which has been linked to increased erosion of telomere length of leukocytes. ...
متن کاملSpurious association between telomere length reduction over time and baseline telomere length.
Ehrlenbach et al. found a linear relationship between baseline relative telomere length (RTL) and the decrease of RTL over 10 years (r1⁄4 0.674; P < 0.001). Similarly, others have reported on this relationship between the telomere attrition rate and the baseline telomere length and found largely similar associations. Likewise, when we correlated the RTL and delta RTL during 7 years of follow-up...
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ژورنال
عنوان ژورنال: European Journal of Epidemiology
سال: 2013
ISSN: 0393-2990,1573-7284
DOI: 10.1007/s10654-013-9845-4